Calsyntenin 1

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August undefined, 2024

WebApr 8, 2009 · Calsyntenin‐1 recruits KLC1 to the TGN and to post‐Golgi organelles. As Kinesin‐1 localizes to the Golgi/TGN 10, 12, we hypothesized that calsyntenin‐1 recruits Kinesin‐1 to TGN membranes.To test this, we cotransfected calsyntenin‐1 with enhanced green fluorescent proteins (EGFP) fused to the N‐terminus (EGFP‐Cst1) and … WebApr 1, 2011 · Calsyntenin-1 was detected through the EGFP tag and KLC1 using the anti-FLAG antibody; images shown are confocal sections. (A) Calsyntenin-1 is highly co-localised with wild-type and both mutant KLC1s in perinuclear regions. In addition calsyntenin-1 and FLAG–KLC1ser460ala co-localise in plasma membrane projections; …

Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with ...

WebDec 1, 2024 · A recent study has shown that LDIR regulates the expression of mir-193b-3p, which targets Calsyntenin 1 (CLSTN1) and serine hydroxymethyltransferase 2 (SHMT2) … WebApr 1, 2008 · The possible role of calsyntenin-1 in learning and memory was suggested by Vogt et al. who first reported a study on calsyntenin-1 . They found that the cytoplasmic acidic region can bind Ca 2+ and proposed that calsyntenin-1 may link extracellular proteolysis in the synaptic cleft and postsynaptic Ca 2+ signaling . Therefore, our … sixth book of new testament

Calsyntenin-1 Docks Vesicular Cargo to Kinesin-1

WebCalsyntenin-1(CLSTN1) plays a critical role in the nervous system, but its relevance in cardiovascular diseases is unknown. We investigated the significance of CLSTN1 in doxorubicin-induced DCM. Methods: CLSTN1 expression in doxorubicin-induced DCM rats and H9c2 cells was determined using western blotting. To further explore the functions of ... WebNov 9, 2024 · Calsyntenin-1(CLSTN1) plays a critical role in the nervous system, but its relevance in cardiovascular diseases is unknown. We investigated the significance of … WebCalsyntenin-1 (CST-1; gene name CLSTN1), also called Alcadein-alpha, is a 140‑150 kDa type I transmembrane glycoprotein that is member of the Alcadein family of cadherin … sushi moto wellington menu

Calsyntenin 1 mRNA expression sensitivity to ionizing …

WebOct 18, 2007 · In primary neuronal cultures, Calstn1-containing organelles were aligned along microtubules and partially colocalized with kinesin-1. These Clstn1-containing … WebDec 5, 2024 · PTHR14139 CALSYNTENIN 1 hit; PTHR14139:SF4 CALSYNTENIN-1 1 hit; PRINTS. PR00205 CADHERIN; PR02045 F138DOMAIN; PROSITE. View protein in … sushi mountainside njWebCalsyntenin-1 (CST-1; also Alcadein-alpha) is a 140 - 150 kDa member of the Alcadein family of molecules. It is expressed in the ER/Golgi and on the plasma membranes of … sixthbornson.com

"WebOct 18, 2007 · In primary neuronal cultures, Calstn1-containing organelles were aligned along microtubules and partially colocalized with kinesin-1. These Clstn1-containing organelles were transported along axons with a velocity and processivity typical for fast axonal transport. Point mutations in the 2 kinesin-binding segments of Clstn1 significantly ... " - Calsyntenin 1

Calsyntenin 1

WebSep 22, 2024 · Calsyntenin-1 mediates hepatitis C virus replication. Awan Z, Tay ESE, Eyre NS, Wu LE, Beard MR, Boo I, Drummer HE, George J, Douglas MWAwan Z, et al. J Gen Virol, 2016 Aug. PMID 27221318; Increased levels of plasma p3-alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease. WebSep 22, 2024 · This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is …

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WebAug 1, 2016 · Calsyntenin-1 has previously been shown to mediate transport of endosomes along microtubules in neurons, through interactions with kinesin light chain-1. Here we demonstrate for the first time, we believe, a similar role for calsyntenin-1 in Huh7 cells, mediating intracellular transport of endosomes. In HCV-infected cells we show that ... WebMar 20, 2012 · Calsyntenin-1 is a neuronally enriched type-1 membrane-spanning protein that binds directly to KLCs via its intracellular C-terminal domain (13– 16). As such, calsyntenin-1 acts as a ligand to mediate transport of a subset of vesicles through axons on kinesin-1 motors.

WebJun 25, 2014 · Calsyntenin-1 is a transmembrane cargo-docking protein important for kinesin-1-mediated fast transport of membrane-bound organelles that exhibits peak expression levels at postnatal day 7. However ... WebJan 1, 2001 · We termed this protein calsyntenin-1, because it binds synaptic Ca 2+ with its cytoplasmic domain. By binding Ca 2+, calsyntenin-1 may modulate Ca 2+-mediated …

WebApr 1, 2008 · The cytoplasmic region of mammalian calsyntenin-1 binds Ca 2+, and it was proposed that calsyntenins may be involved in proteolysis-dependent modulation of synaptic functions through its Ca 2+-binding capacity (13, 26). Based on this idea, the cytoplasmic region of CASY-1 may be essential for learning in C. elegans. WebNov 9, 2024 · Calsyntenin-1 (CLSTN1), a type I transmembrane protein, is a member of the cadherin superfamily of cell-adhesion molecules. Although the brain displays the highest levels of expression, CLSTN1 can also be …

WebMar 21, 2024 · Entrez Gene Summary for CLSTN1 Gene. This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) …

WebRayBio® Human Calsyntenin-1 (Alcadein-alpha) ELISA Kit. 4 - 7 week lead time. This ELISA uses an antibody pair and standard that have been validated for multiplex array … sixth boro graphicsWebJul 1, 2012 · Calsyntenin-1 is a ligand for kinesin-1 light chains and APP is transported through axons on kinesin-1 molecular motors. Defects in axonal transport are an early … sushi moto yonge streetWebCalsyntenin-1 is abundant in most neurons of the CNS [47] where it has been shown to modulate postsynaptic calcium signalling and promote dendritic spine assembly [19]. We quantified calsyntenin-1 using two proteotypic peptides (GNLAGLTLR, IISTITR) as internal standards, both of which are located in the extracellular domain common to both ... sushi mount doraWebJul 9, 2014 · Here we identify a kinesin adaptor, Calsyntenin-1 (Clstn-1), as an essential regulator of axon branching and neuronal compartmentalization in vivo. We use morpholino knockdown and a Clstn-1 mutant to show … sushi mountain roadWebJun 25, 2014 · Calsyntenin-1 is a transmembrane cargo-docking protein important for kinesin-1-mediated fast transport of membrane-bound organelles that exhibits peak expression levels at postnatal day 7. … sixth book of outlanderWebJun 7, 2006 · Calsyntenin-1 Is Enriched in Axonal Growth Cone Vesicles. The presence of calsyntenin-1–containing organelles in developing axons led us to presume that these … sushi mount airyWebThe calsyntenin-1 is located in the postsynaptic membrane of CNS synapses and a proteolytically processed protein of the postsynaptic membrane with a calcium-binding cytoplasmic domain. Calsyntenin-1 is a dynamic modulator of postsynaptic calcium by extracellular proteolysis. Calsyntenin-1 may modulate Ca2+ transients locally either … sushi mountain view castro street