Cisplatin hplc method
WebJun 13, 2005 · Cisplatin, cisplatinum or cis-diamminedichloroplatinum (II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes … Webderivitized cisplatin [21]. The objective of study was to develop and validate a direct and effective HPLC method for the simultaneous determination of etoposide and cisplatin which could be used in quality control analysis. The present work therefore is a direct method with good linearity and sensitivity for both drugs. O O O H HO H HO O O O O ...
Cisplatin hplc method
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WebApr 1, 2012 · The HPLC method was developed using C 18 ODS Hypersil column of 250 × 4.6 mm id with 5 µm particle size, mobile phase of water : methanol : acetonitrile (40:35:25, v/v/v, pH 3.5) at a flow rate... WebApr 24, 2024 · Doxorubicin hydrochloride. Several methods such as LC-MS, reverse phase HPLC and UV-Visible spectrometry have been reported and validated for quantitative analysis of doxorubicin hydrochloride in bulk and pharmaceutical dosage forms [12,13,14, 22, 23].All these methods require use of solvents, however due to unstable …
Webinjected onto the HPLC system. Retention time of cisplatin, mono-chloride, OH-dimer, and none-chloride was 3.2, 3.4, 3.6, and, 4.3–6.6 min, respectively. Measurable ranges with this method were 1˜10˚5 to 4˜10˚3 M for cisplatin. Correlation coefficient of the calibration curves of cisplatin was 0.999 (p<0.01). The within- and WebNov 1, 2008 · Purpose: The purpose of this study was to develop and validate HPLC-UV method for the determination of the cisplatin, based …
WebDownload scientific diagram Cisplatin determination by HPLC method. Chromatogram shows the peak of chelating agent, diethyldithiocarbamate (DDTC), and cisplatin in … WebNational Center for Biotechnology Information
WebSep 1, 2024 · Application of a newly developed HPLC method to evaluate the drug release of co-loaded 5-fluorouracil and cisplatin films. Abstract The combination of 5-fluorouracil (5-FU) and cisplatin (Cis) has been used for the treatment of many cancers.
WebJun 12, 2000 · In water, the antineoplastic drug cisplatin, cis-[PtCl2(NH3)2] (1) hydrolyses slowly to the aqua complexes cis-[Pt(NH 3) 2 Cl(H 2 O)] + (2) and, to a small extent, cis-[Pt(NH 3) 2 (H 2 O) 2] 2+ (3), which are thought to play an important role in the metabolism of cisplatin.HPLC is a useful technique for monitoring 2 and 3, but only if the … highest trekking point in indiaWebHPLC Analysis of Cisplatin and Monohydrated Cisplatin on SeQuant ZIC-HILIC. Home Small Molecule HPLC HPLC Analysis of Cisplatin and Monohydrated Cisplatin on … highest trophic levelWebA high-performance liquid chromatographic (HPLC) method is described for the determination of residual levels of cisplatin from extracts of surfaces with very low … how henna hr dye worksWebCisplatin, referred to by chemical name as cis-diamminedichloroplatinum (II), is anticancer, neutral and DNA destroying agent that is square planar platinum (II) complex and contains 2 ligands of chloride in a cis configuration orientation. 1 Cisplatin has been cited as being among the most used cytotoxic anticancer medication due to its ... highest tretinoin strengthhttp://www.ijsit.com/admin/ijsit_files/ijsit_1.1.5.pdf highest trophic level in the food chainWebHigh-performance liquid chromatography of cisplatin The retention behavior of cisplatin on a variety of stationary phases has been investigated using aqueous mobile phases … highest troponin level recordedWebIn this work, a new sensitive and selective method of determining cisplatin-DNA adducts based on the use of element-selective mass spectrometry is proposed, and the method is then applied to detect cisplatin adducts induced … highest troponin ever recorded