WebNov 15, 2024 · In addition to downregulating MYC- and E2F-driven transcription, CDK7 inhibition caused a rapid decrease in MYC protein abundance and impaired the oncogenic MYC-regulated glycolytic cascade in MM. The resulting increase in reactive oxygen species and DNA damage is likely the mechanism for the observed tumor cell apoptosis caused … WebMar 9, 2024 · Through its 49 role as a critical cofactor and regulator of MYC and E2F activity, CDK7 is therefore a master 50 regulator of oncogenic cellular programs supporting MM growth and survival, and a valuable 51 therapeutic target providing rationale for development of YKL-5-124 for clinical use. 52 53 54 55 56 57 58 59 60 3 Introduction 61 …
A direct role of transcription factor E2F in c-myc gene …
WebThe first is a result of mitogen stimulation though the ERK leading to the expression of the transcription factor Myc, which is a direct activator of E2F. The second pathway is a result of ERK activation leading to the … WebE2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes.Three of them are activators: E2F1, 2 and E2F3a. Six others act as … durham school of the arts admission
E2F2 - an overview ScienceDirect Topics
WebMar 6, 2024 · Here, we show that CDK7 expression positively correlates with E2F and MYC transcriptional programs in multiple myeloma (MM) patient cells; and its selective targeting counteracts E2F activity via perturbation of the CDKs/Rb axis and impairs MYC … WebAug 29, 2024 · 29 Aug 2024 by Datacenters.com Colocation. Ashburn, a city in Virginia’s Loudoun County about 34 miles from Washington D.C., is widely known as the Data … WebAug 1, 2004 · Perhaps most surprisingly, E2F also regulates many genes with functions in processes that are unrelated to cell cycle progression such as DNA damage repair, apoptosis, differentiation and development. Furthermore, many negative regulators of cell growth are induced by E2F and numerous genes are repressed upon its overexpression. 2. durham school of the arts high school