WebJun 11, 2024 · HEPN-1 is composed of ten α-helices, and HEPN-2 domain is composed of eleven α-helices. Two HEPN domains interact with each other primarily through helix-α3 … WebJan 31, 2024 · The Helical-3 domain was close to the HEPN-2 domain, and target RNA recognition facilitated the formation of HEPN domain that decided the nuclease activity of Cas13a protein. Our calculations were consistent with previous reports studying the mechanisms of Cas13a activity [9, 23, 24]. These results suggest that hairpin-spacer …
HEPN: a common domain in bacterial drug resistance and …
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Alternative dimerization is required for activity and inhibition …
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