WebFeb 1, 2011 · IRF8-null mice (IRF8 −/ ... Fig. 3A illustrates the strategy for conditional deletion of exon 2 of Irf8. The floxed and WT alleles were detected by PCR in genomic DNA . After crossing with CD19-Cre mice, the homozygous Irf8 f/f mice bearing the Cre gene exhibited a complete depletion of IRF8 protein in splenic B cells . In the BM ... WebCopies of IRF8 flox or delta locus/ reference gene locus CD45.2 (normalized) ... Mononuclear phagocyte composition in Itgax-cre.Irf8fl/fl or fl/- and Irf8fl/fl mice and effect of Irf8 haplo-insufficiency on intestinal DC subset composition, related to Figure 1. (A and C) Representative flow cytometry plots and (B and D) ...
Transcription factors IRF8 and PU.1 are required for follicular B …
WebEarly life and education. Fredericks was born of Scandinavian descent in Rock Island, Illinois, on January 31, 1908. [citation needed] His family moved to Florida for a short time and … WebMar 8, 2024 · SSc remain unknown. IRF8 is a transcriptional regulator that is essential for the differentiation and function of monocytes and macrophages and thus may be involved in the regulation of macrophage phenotypes in SSc fibrosis. In this study, we measured IRF8 levels in circulating monocytes of 26 patients with SSc (diffuse cutaneous SSc, iotransfer could harm your device
IRF8 Monoclonal Antibody (V3GYWCH), PE (12-9852-82)
WebUpon arrival, some Irf8 f mice were bred with B6.Cg-Tg(Sox2-cre)1Amc/J mice (Stock No. 008454) for germline removal of floxed exon 2. Offspring with pan deletion of floxed exon … WebJun 21, 2024 · We generated a mouse line with Irf8 -deficiency in Clec9a -expressing progenitors and hypothesized that Irf8 -deficiency would deplete cDC1s, which may promote a pro-inflammatory immune response and consequently drive AKI/AKD progression. Materials and Methods Animals WebInterferon regulatory factor 8 (Irf8), also known as interferon consensus sequence-binding protein, is a component of the Irf transcription factor family. Irf8 is differentially expressed … iot pwn 题目