Myocardin-related

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August undefined, 2024

WebEndothelial–mesenchymal transition (EndMT) is a crucial phenomenon in regulating the development of diseases, including cancer metastasis and fibrotic disorders. The primary regulators of disease development are zinc-finger transcription factors belonging to the Snail family. In this study, we characterized the myocardin-related transcription factor … WebMyocardin-related transcription factors (MRTFs) are serum response factor (SRF) cofactors that promote a smooth muscle phenotype and are emerging as components of stress-responsive signaling. Objective: We aimed to examine the effect of MRTF-A on cardiac remodeling and fibrosis.

Modulating Myofibroblastic Differentiation of Fibroblasts through …

WebMyocardin-related transcription factors (MRTFs), through their interaction with the serum-response factor (SRF) on CArG box regulatory elements (CC(A/T) 6 GG), are important regulators of myofibroblast differentiation. MRTF-A transactivated type I collagen gene reporters as much as 100-fold in lung myofibroblasts. Loss of functional MRTF-A ... ouat maleficent lily

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in

WebMar 29, 2024 · These proteins are active in signaling pathways related to expression of pro-inflammatory cytokines and IFN, inflammasome assembly and activation, cytoskeleton regulation and SMC contraction, mitochondrial integrity and cellular response to oxidative stress, proteostasis control via ubiquitination, and cell proliferation and epithelial-to ... WebMar 16, 2024 · Myocardin-related transcription factors (MRTFs: MYOCD, MRTF-A/ MKL1, and MRTF-B/ MKL2) are strong activators of a subset of serum response factor- (SRF) … WebApr 8, 2024 · Distant metastasis is one of the leading causes of cancer-related mortality of colorectal cancer (CRC). Dysregulation of E3 ubiquitin ligases has been implicated in acting vital roles in multiple cancers. ... Treisman R. Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell ... ouat merit list

Myocardin-Related Transcription Factor-A Circulation Research

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WebOct 23, 2002 · Here we describe two myocardin-related transcription factors (MRTFs), A and B, that also interact with SRF and stimulate its transcriptional activity. Whereas … WebMay 18, 2024 · The Myocardin family of transcription factors, which include Myocardin (MYOCD) and Myocardin-related transcription factors (MRTFs), are critical for SMC differentiation and maintenance of the contractile phenotype . MRTFs also bind G-actin and can be sequestered in the cytoplasm by actin monomers. When actin polymerizes, the … rodney chamnessWebMar 29, 2024 · myocardin-related transcription factor A Names MKL/myocardin-like protein 1 alternative protein MKL1 basic, SAP and coiled-coil domain megakaryoblastic leukemia … ou at isu

"WebDec 21, 2016 · This editorial refers to ‘Inhibition of SRF/myocardin reduces aortic stiffness by targeting vascular smooth muscle cell stiffening in hypertension’ by Zhou et al., pp. 171–182.. Large artery stiffening is a main risk factor for chronic diseases including aging-related hypertension, heart failure, renal disease, stroke and dementia, which represent … " - Myocardin-related

Myocardin-related

WebJan 1, 2015 · Myocardin-related transcription factor (MRTF)-A and MRTF-B (MKL1 and MKL2, respectively) are enriched in the perinuclear space of epicardial cells during development. Transforming growth factor (TGF)-β signaling and disassembly of cell contacts leads to nuclear accumulation of MRTFs and the activation of the motile gene … WebOct 15, 2024 · OA is the most common motor system degenerative disease in middle-aged and elderly individuals, with a survey showing that the prevalence of symptomatic OA in men and women over 60 years old was 18.0 and 9.6%, respectively.

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WebMyocardin-Related Transcription Factors A and B (MRTF-A and MRTF-B) are highly homologous proteins that function as powerful coactivators of serum response factor (SRF), a ubiquitously expressed transcription factor essential for cardiac development. Myocardin is a protein that in humans is encoded by the MYOCD gene. Myocardin is a smooth muscle and cardiac muscle-specific transcriptional coactivator of serum response factor. When expressed ectopically in nonmuscle cells, myocardin can induce smooth muscle differentiation by its association with serum response factor (SRF; MIM 600589).[supplied by OMIM]

WebJan 1, 2015 · Myocardin-related transcription factor (MRTF)-A and MRTF-B (MKL1 and MKL2, respectively) are enriched in the perinuclear space of epicardial cells during … WebDec 25, 2014 · Myocardin (MYOCD) is a potent transcriptional coactivator that functions primarily in cardiac muscle and smooth muscle through direct contacts with serum …

WebApr 8, 2024 · The opposed gene expression of contractile genes and Egr1, which is tightly regulated by the transcriptional co-activators myocardin and myocardin-related transcription factors (MRTFs) and the ternary complex factor ETS like protein Elk-1, which compete for the binding to the transcription factor serum response factor (SRF) … WebJul 23, 2010 · Myocardin-related transcription factor-A controls myofibroblast activation and fibrosis in response to myocardial infarction. Circ Res. 2010; 107: 294–304. Link Google Scholar. 8 Parmacek MS. Myocardin-related transcription factors: critical coactivators regulating cardiovascular development and adaptation.

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WebHER2 receptor tyrosine kinase that is overexpressed in approximately 20% of all breast cancers (BCs) is a poor prognosis factor and a precious target for BC therapy. Trastuzumab is approved by FDA to specifically target HER2 for treating HER2+ BC. However, about 60% of patients with HER2+ breast tumor develop de novo resistance to trastuzumab, partially … rodney chambleeWebThe regulatory effects of surface micropatterns on the myofibroblastic differentiation of fibroblasts were investigated. Compared to the flat surfaces and surfaces with micro pit, surfaces with micro columns triggered the F- to G-actin transition, inhibiting the nuclear transfer of myocardin-related transcription factor-A. rodney champnessWebFeb 13, 2024 · MKL1, a mechanosensitive transcription factor belonging to the family of Myocardin-related transcription factors (MRTFs), is a coactivator that, following serum stimulation, translocates into the nucleus and physically associates with the Serum Response Factor, thereby transducing cytoskeletal signals to the nucleus and activating a … rodney chambers obituary