Organic anion transporter drugs

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August undefined, 2024

Witryna Aims Witryna9 cze 2010 · The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver. The excretion of OTA into urine is thought to be mainly by tubular secretion, presumably via the organic anion transport system. Recently, several families of …

Organic Anion Transporter - an overview ScienceDirect Topics

Witryna21 paź 2024 · Organic anion transporter 2 (OAT2 or SLC22A7) plays an important role in the hepatic uptake and renal secretion of several endogenous compounds and drugs. The goal of this work is to understand the structure activity of OAT2 inhibition and assess clinical drug interaction risk. A single-point inhibition assay using OAT2-transfected … WitrynaOrganic anion transporters (OATs) are the secondary/tertiary active transporter proteins that regulate anion balance in the body. They are primarily expressed in the kidney and liver and control the excretion of common drugs, toxins, and endogenous metabolites into the urine. now sky cinema free trial

Organic anion transporters: discovery, pharmacology, regulation …

Witryna Witryna2 sie 2010 · Organic anion transporting polypeptides (OATPs) are uptake transporters for a broad range of endogenous compounds and xenobiotics. To investigate the physiologic and pharmacologic roles of OATPs of the 1A and 1B subfamilies, we generated mice lacking all established and predicted mouse Oatp1a/1b transporters … WitrynaThe organic anion transporter (OAT) family handles a wide variety of clinically important compounds (antibiotics, nonsteriodal anti-inflammatory drugs, etc.) and toxins. However, little is known about their appearance during development despite documented differences in the handling of anionic drugs among neonates, children, and adults. nics interview presentation

Positive correlation between organic anion transporter 1B …

Pharmacogenomics of human OATP transporters SpringerLink

WitrynaOrganic Anion Transporters Proteins involved in the transport of organic anions. They play an important role in the elimination of a variety of endogenous substances, … WitrynaBeneficial herb-drug interaction of rhein in Jinhongtang and Imipenem/Cilastatin mediated by organic anion transporters J Ethnopharmacol . 2024 Apr 4;116449. … now sky sports offerWitrynaHowever, a marked disconnect in the in vitro-in vivo (IVIV) translation of hepatic clearance is often noted for these drugs. Metabolic rates measured using human liver … now sky sports pass

"WitrynaBeneficial herb-drug interaction of rhein in Jinhongtang and Imipenem/Cilastatin mediated by organic anion transporters J Ethnopharmacol . 2024 Apr 4;116449. doi: 10.1016/j.jep.2024.116449. " - Organic anion transporter drugs

Organic anion transporter drugs

Drug transport by Organic Anion Transporters (OATs) - PubMed

Witryna22 paź 2024 · Organic anion transporter 2 (OAT2 or SLC22A7 ) plays an important role in the hepatic uptake and renal secretion of several endogenous compounds and … Witryna1 lip 2012 · Organic anion transporters play an essential role in the distribution and excretion of numerous endogenous metabolic products and exogenous organic …

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The OATPs play a role in the transport of some classes of drugs across the cell membrane, particularly in the liver and kidney. In the liver, OATPs are expressed on the basolateral membrane of hepatocytes, transporting compounds into the hepatocyte for biotransformation. A number of drug-drug interactions have been associated with the OATPs, affecting the pharmacokinetics and pharmacodynamics of drugs. This is most commonly where one drug inhi… WitrynaCommon to all so far functionally characterized Organic Anion Transporters (OATs) is their broad substrate specificity and their ability to exchange extracellular …

WitrynaThe sulfate-anion antiporter 1 (SAT-1; hsat-1) may also contribute to organic anion transport at the basolateral membrane. On the apical membrane, the multi-drug … WitrynaOrganic anion transporters were first identified in intestine, liver, and kidney based on extensive studies of membrane transport phenomena mainly of xenobiotics. Recent advances in membrane transport studies with the use of molecular biological approaches have confirmed the participation of such carrier-mediated transport in …

Aims WitrynaOrganic anion transporters play an essential role in the distribution and excretion of numerous endogenous metabolic products and exogenous organic anions, including …

WitrynaThe organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a …

WitrynaThe Organic Anion Transporter 4 (OAT4, SLC22A9) This transporter was cloned from a human kidney cDNA library (53). Orthologues from other species have not … nics.intranet.nigov.netbbc newsWitrynaThe ability of an antineoplastic drug to exert its cytostatic effect depends largely on the balance between its uptake into and extrusion from the cancer cells. ... the organic … now sky sports pass offerWitryna1 sty 2015 · The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of attention because of its role in handling of common drugs (antibiotics, antivirals, diuretics, nonsteroidal anti-inflammatory drugs), toxins (mercury, aristolochic acid), … now sky sports tvWitrynathat MRP3 is an organic anion and multidrug transporter, like the GS-X pumps MRP1 and MRP2. In Madin–Darby canine kidney II cells, MRP3 routes to the basolateral … nics international womens dayWitryna8 cze 1999 · Our results show that MRP3 is an organic anion transporter and transports DNP-GS, like MRP1 and MRP2. Moreover, MRP3 can cause resistance to … nics.intranet.nigov.net bbcsoundsWitrynaThe Organic Anion Transporter 1B1 (OATP1B1) and Statin-Induced Myopathy. OATP1B1 is a genetically polymorphic influx transporter that is encoded by … now sky sports voucherWitryna30 cze 2024 · Both uptake and efflux drug transporters are involved in kidney toxicity of some drugs. Source: reprinted from basit, radi, vaidya, karasu, prasad, ©2024. MATE, multidrug and toxin extrusion; MRP, multidrug resistance–associated protein; OAT, organic anion transporter; OCT, organic cation transporter; SGLT, sodium … nics invoice